Effects of Reduced Gadolinium-Based Contrast Agents (GBCA) Volumes on MRI Image Quality: An Experimental Phantom Study

  • F. Ahmad Anwar Universiti Teknologi MARA
  • N. Ismail National Cancer Institute
  • F. Zakaria Universiti Teknologi MARA

Abstract

Many recent studies focused on the patient’s safety from the administration of gadolinium-based contrast agents (GBCAs), their concentration, the dose of administration and their effects on the image quality. The present study was aimed at evaluating the effects of reduced GBCAs (gadobutrol and gadoterate meglumine) volume on the image quality by using phantoms. Eight (8) human brain mimicking phantom made of nickel chloride (NiCl2) doped agarose gel were added with 0.00500 ml (100% volume), 0.00350 ml (75% volume), 0.00250 ml (50% volume) and 0.00125 ml (25% volume) of gadobutrol, 0.0100 ml (100% volume), 0.0075 ml (75% volume), 0.0050 ml (50% volume) and 0.0025 ml (25% volume) of gadoterate meglumine. The phantoms were scanned using a 1.5-T and a 3 T-MRI system. Signal-to-noise ratio (SNR) and the contrast agents enhancement were evaluated quantitatively and qualitatively. The 50% volume of gadobutrol and gadoterate meglumine at 3 T showed greater enhancement when compared with 50% and 100% volumes of gadobutrol and gadoterate meglumine at 1.5 T. It can be concluded that the volume of gadobutrol and gadoterate meglumine contrast agents can be reduced when using a higher field system.

Author Biographies

F. Ahmad Anwar, Universiti Teknologi MARA

Centre for Medical Imaging, Faculty of Health Sciences, Universiti Teknologi MARA Kampus Selangor, Bandar Puncak Alam, Selangor Darul Ehsan

N. Ismail, National Cancer Institute

Department of Radiology, National Cancer Institute, Jalan P7, Presint 7, 62250 Putrajaya, Wilayah Persekutuan Putrajaya

F. Zakaria, Universiti Teknologi MARA

Centre for Medical Imaging, Faculty of Health Sciences, Universiti Teknologi MARA Kampus Selangor, Bandar Puncak Alam, Selangor Darul Ehsan

Published
2021-02-10
How to Cite
AHMAD ANWAR, F.; ISMAIL, N.; ZAKARIA, F.. Effects of Reduced Gadolinium-Based Contrast Agents (GBCA) Volumes on MRI Image Quality: An Experimental Phantom Study. Physics and Technology in Medicine, [S.l.], v. 1, n. 2, p. 32-39, feb. 2021. ISSN 2710-723X. Available at: <https://myjms.mohe.gov.my/index.php/ptm/article/view/11009>. Date accessed: 10 aug. 2022.