The Effect of Resistance Training to Failure on Insulin Sensitivity and Muscle Adaptations in Overweight Men
Background: Insulin resistance, systemic inflammation, body fat development, and energy imbalances are all associated with inactivity. In Asian populations, resistance training (RT) has been proven to be similarly helpful for diabetic controls. RT voluntary to failure is the inability to perform a repetition over a full range of motion with a given overload due to fatigue and more advantageous since it ensures the recruitment of most motor units and muscle fibres. Objective: To investigate the effects of 6 weeks of resistance exercise training, compromised of 1 session/week (RT1) and 3 sessions/week (RT3) voluntary to failure on overweight men. Besides that, this study also determine the early time – course of RT voluntary to failure on muscle strength, and muscle mass on overweight men. Methods: 20 overweight men have engaged in a program of 6 weeks RT voluntary to failure. The exercises consist of upper and lower exercises; inclined leg press, bench press, leg extension, shoulder press, hip abduction, seated row, calf raise, latissimus pulldown, and biceps curl. For group RT1, participants performed the exercise in one session per week, while participants of group RT3 did the exercise in 3 sessions per week. Each participant performed approximately 60 minutes of RT voluntary to failure every week at 80% of their one-repetition maximum (1RM) effort. The 1RM test was performed at baseline, week 3 of RT and post–intervention while insulin sensitivity (HOMA – IR) was performed at baseline and post-intervention. Result: Insulin sensitivity – HOMA-IR difference of 1.07% (RT1) and 2.78% (RT3), Muscle mass (kg) increment of 1.44% (RT1) and 1.13% (RT3), and body fat (%) decrement of 1.41% (RT1) and 2.95% (RT3). The differences in the total sum of strength for both groups were not more than 10% of the nine exercises RT voluntary of failure for 6 weeks, 3891kg (RT1) and 3745kg (RT3). Conclusion: An improvement in insulin sensitivity (HOMA – IR), muscle mass (kg) and body fat (%) were seen after 6 weeks of single–set RT voluntary to failure in both groups. However, RT1 had an improvement in muscle mass only while RT3 had good results in insulin sensitivity and body fat (%). Both groups experienced an increase in muscle strength. By our findings, RT voluntary to failure can assist those in overweight population to improve their insulin sensitivity and muscle adaptations and it can also be utilised as a substitute for those who had a time constraint to exercise.
Bell, S. (2009). Experimental Design. International Encyclopedia of Human Geography, 672–675. https://doi.org/10.1016/B978-008044910-4.00431-4
Brad, S., Nicholas, R., Mark, P., Bret, C., G, S., & Brent, A. (2014). Effects Of different volume-equated resistance training loading strategies on muscular adaptions in well-trained men. Journal of Strength and Conditioning Research, 28(10), 2909–2918.
Campa et al. (2020). Effects-of-different-resistance-training-frequencies-on-body-composition-cardiometabolic-risk-factors-and-handgrip-strength-in-overweight-and-obese-women-A-randomized-controlled-trialJournal-of-Functional-Morphology.pdf. Journal of Functional Morphology and Kinesiology. https://doi.org/https://doi.org/10.3390/jfmk5030051
Celis-Morales, C. A., Welsh, P., Lyall, D. M., Steell, L., Petermann, F., Anderson, J., Iliodromiti, S., Sillars, A., Graham, N., MacKay, D. F., Pell, J. P., Gill, J. M. R., Sattar, N., & Gray, S. R. (2018). Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: Prospective cohort study of half a million UK Biobank participants. BMJ (Online), 361, 1–10. https://doi.org/10.1136/bmj.k1651
Fisher, J., Steele, J., Bruce-Low, S., & Smith, D. (2011). Evidence-Based Resistance Training Recommendations. Medicina Sportiva, 15(3), 147–162. https://doi.org/10.2478/v10036-011-0025-x
Hameed, U. A., Manzar, D., Raza, S., Shareef, M. Y., & Hussain, M. E. (2012). Resistance training leads to clinically meaningful improvements in control of glycemia and muscular strength in untrained middle-aged patients with type 2 diabetes mellitus. North American Journal of Medical Sciences, 4(8), 336–343. https://doi.org/10.4103/1947-2714.99507
Han, S. J., Boyko, E. J., Kim, S. K., Fujimoto, W. Y., Kahn, S. E., & Leonetti, D. L. (2018). Association of thigh muscle mass with insulin resistance and incident type 2 diabetes mellitus in Japanese americans. Diabetes and Metabolism Journal, 42(6), 488–495. https://doi.org/10.4093/dmj.2018.0022
Ismail, A. D., Alkhayl, F. F. A., Wilson, J., Johnston, L., Gill, J. M. R., Gray, S. R., Stefanaki, D. G. A., Dzulkarnain, A., & Gray, S. R. (2019). The effect of short-duration resistance training on insulin sensitivity and muscle adaptations in overweight men. Experimental Physiology, 104(12), 1375–1380. https://doi.org/10.1080/02640414.2018.1559536
Ismail, A. D., Syahirah, S., Shafee, A., Bakar, A. A., Kamaruddin, H. K., Ain, E., & Aznan, M. (2022). The Effect of Resistance Training on Insulin Sensitivity : A Systematic Review Faculty of Sports Science and Recreation , Universiti Teknologi MARA , Perlis Branch , Arau Institute of Cardiovascular and Medical Sciences , University of Glasgow , Glasgow ,. 11(2), 1–16.
Jenkins, N. D. M., Miramonti, A. A., Hill, E. C., Smith, C. M., Cochrane-Snyman, K. C., Housh, T. J., & Cramer, J. T. (2017). Greater neural adaptations following high- vs. low-load resistance training. Frontiers in Physiology, 8(MAY), 1–15. https://doi.org/10.3389/fphys.2017.00331
Jessee, M. B. (2018). A Comparison of the Acute Muscular Response and Long-term Adaptation to Resistance Training Using Traditional High Loads or Very Low Loads with Different Degrees of Blood Flow Restriction in the Lower Body. ProQuest Dissertations and Theses, May, 144. https://www.proquest.com/dissertations-theses/comparison-acute-muscular-response-long-term/docview/2059300883/se-2?accountid=17256%0Ahttp://surrey-primotc.hosted.exlibrisgroup.com/openurl/44SUR/44SUR_services_page?genre=dissertations+%26+theses&issn=&titl
Mitchell, C. J., Churchward-Venne, T. A., West, D. W. D., Burd, N. A., Breen, L., Baker, S. K., & Phillips, S. M. (2012). Resistance exercise load does not determine training-mediated hypertrophic gains in young men. Journal of Applied Physiology, 113(1), 71–77. https://doi.org/10.1152/japplphysiol.00307.2012
Samuelson, G. (2004). Global strategy on diet, physical activity and health. Scandinavian Journal of Nutrition/Naringsforskning, 48(2), 57. https://doi.org/10.1080/11026480410034349
Schoenfeld, B. J., Contreras, B., Krieger, J., Grgic, J., Delcastillo, K., Belliard, R., & Alto, A. (2019). Resistance Training Volume Enhances Muscle Hypertrophy but Not Strength in Trained Men. Medicine and Science in Sports and Exercise, 51(1), 94–103. https://doi.org/10.1249/MSS.0000000000001764
Stefanaki, D. G. A., Dzulkarnain, A., & Gray, S. R. (2019). Comparing the effects of low and high load resistance exercise to failure on adaptive responses to resistance exercise in young women. Journal of Sports Sciences, 37(12), 1375–1380. https://doi.org/10.1080/02640414.2018.1559536
Trost, S. G., Owen, N., Bauman, A. E., Sallis, J. F., & Brown, W. (2002). Correlates of adults’ participation in physical activity: Review and update. Medicine and Science in Sports and Exercise, 34(12), 1996–2001. https://doi.org/10.1097/00005768-200212000-00020
Warburton, D., Jamnik, V., Bredin, S., Shephard, R., & Gledhill, N. (2021). The Physical Activity Readiness Questionnaire for Everyone. The Health & Fitness Journal of Canada, 14(1), 83–87. https://www.who.int/publications/i/item/9789240015128
Wolfe, R. R. (2006). The underappreciated role of muscle in health and disease. American Journal of Clinical Nutrition, 84(3), 475–482. https://doi.org/10.1093/ajcn/84.3.475
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