Relationship Between Concomitant Atopic Diseases With Atopic Dermatitis Severity And Persistence.

  • Adawiyah Jamil Department of Medicine, University Kebangsaan Malaysia Medical Center, Kuala Lumpur
  • Siew Wen Goh Department of Medicine, University Kebangsaan Malaysia Medical Center, Kuala Lumpur
  • Chon Sian Lee Department of Dermatology, Hospital Tuanku Ja'afar, Seremban, Negeri Sembilan
  • Mohan Arumugam Department of Medicine, University Kebangsaan Malaysia Medical Center, Kuala Lumpur

Abstract

Introduction: The atopic march consists of atopic dermatitis (AD), allergic rhinitis or sinusitis (AR), allergic conjunctivitis (AC) and bronchial asthma (BA). The influence of concomitant atopic diseases on AD is under-explored. We determined the relationship between personal and family history of atopic diseases with AD severity and persistence. Methods: A cross sectional study involving AD patients was performed at dermatology clinics of two tertiary hospitals. Inclusion criterion was all patients diagnosed with AD. Demographic data, personal and family history of atopy (BA, AR and AC) were obtained by face-to-face interview. AD severity was evaluated using Investigator’s Global Assessment (IGA). AD was considered persistent if continued beyond age 12 years. Results: Sixty patients aged 21.6±17.2 participated. There were 25(41.7%) with concomitant AR, 16(26.7%) BA and 12(20%) AC. Forty seven (78.3%) patients had family history of atopy, 25(41.7%) had eczema, 24(40%) AR, 19(31.7%) BA and 2(3.3%) AC. Patients with BA [OR=3.8, 95%CI 1.04 to 14.4)], BA and AR [OR=9.74, 95%CI 1.13 to 83.67) and family history of BA [OR= 4.00, 95%CI 1.20 to 13.27) were more likely to exhibit moderate-severe AD. Personal AR, AC and family history of AD and BA were significantly more prevalent in patients with persistent AD. Conclusions: AR was the most common atopic disease associated with AD. Family history of eczema and AR were common. Personal BA, BA with AR and family history of BA were predictors of severe AD. Personal AR, AC and family history of AD and BA were associated with AD persistence.

Published
2021-08-24
How to Cite
JAMIL, Adawiyah et al. Relationship Between Concomitant Atopic Diseases With Atopic Dermatitis Severity And Persistence.. Journal of Clinical and Health Sciences, [S.l.], v. 6, n. 2, p. 43-47, aug. 2021. ISSN 0127-984X. Available at: <https://myjms.mohe.gov.my/index.php/JCHS/article/view/9507>. Date accessed: 26 sep. 2021. doi: https://doi.org/10.24191/jchs.v6i2.9507.

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